ONE Instant Messenger Tool to Use Them All!
I recommend Trillian to all affiliate managers out there, for high availability via IM, to your affiliates.
Trillian does not support Skype by default, but there is a free add-on called SkyLian (beta), written by Nicolas Begorre, which is available on his website for download. The add-on integrates Skype into Trellian V3, but not as nice as the other instant messenger services. You must have Skype installed also though.
Please see the SkyLian setup and configuration guides for details.
Additional Useful Resources